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7 More modern cartilage regeneration approaches include autologous chondrocyte implantation (ACI) and now matrix-associated autologous chondrocyte implantation (MACI), as well as autologous matrix-induced chondrogenesis (AMIC)

[20] Pernicious anemia may be present without a person experiencing symptoms at first, over time, feeling tired and weak, lightheadedness, dizziness, headaches, rapid or irregular heartbeat, breathlessness, glossitis (a sore red tongue), poor ability to exercise, low blood pressure, cold hands and feet, pale or yellow skin, easy bruising and bleeding, low-grade fevers, tremor, cold sensitivity, chest pain, upset stomach, nausea, loss of appetite, heartburn, weight loss, diarrhea, constipation, severe joint pain, feeling abnormal sensations including tingling or numbness to the fingers and toes ( pins and needles ), and tinnitus, may occur

However, some patients may experience mild swelling and redness at the injection site, upset stomach, or light headedness

A., Pfeiffer C

How long the effects last varies