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We used four criteria for estimation of the edema: a pale myelin, sieve-like appearance of myelinated areas, dilation of perivascular and pericellular spaces and vacuolar appearance of the neuropil of gray matter

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What remains uncertain is whether the current body of evidence is large enough to detect rare or long-term effects that may only become apparent after years of observation

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Using the enzymatic characteristics of NQO1, a variety of NQO1-activated optical probes for imaging different cells in various tissues, including the brain, have been developed [279]