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Why did dihexa never enter clinical trials if the animal data was promising? Pharmaceutical companies evaluate preclinical compounds based on risk-benefit calculus, intellectual property landscape, competitive market positioning, and probability of regulatory approval many promising animal compounds are abandoned before human trials because the investment required for Phase 13 studies (often $50$100 million) cannot be justified

Late-onset cases generally have a milder clinical phenotype with acute or slowly progressive neurologic symptoms and behavioral disturbances (06)

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Voss, J

Understanding the nature of these electrophiles is crucial for developing new drugs and studying metabolic pathways