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46 Magnesium in Inflammation and Oxidative Stress In preclinical, epidemiological, and clinical human studies, magnesium deficiency, low serum magnesium levels, and reduced dietary magnesium intake have consistently been linked to heightened production of reactive oxygen species (ROS), low-grade inflammation, and elevated levels of inflammatory markers and pro-inflammatory moleculesincluding interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-), interleukin-1 beta (IL-1), vascular cell adhesion molecule-1 (VCAM-1), plasminogen activator inhibitor-1 (PAI-1), complement proteins, 2-macroglobulin, and fibrinogen