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Whole-genome and comparative metagenomic studies showed that these organisms have detailed pathways for breaking down complex carbohydrates, producing SCFAs, transforming bile acids, and creating surface or secreted molecules that modulate the immune system (95)

Also, in the context of oxidative stress, the vitamin E binding protein AFM was less abundant in the individuals with type 1 diabetes than in the UFMs

The compounds act as ROS scavengers, inhibit ROS-generating enzymes, and activate the endogenous antioxidant system (135)

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COVID-19 patients also display diffused white matter damage, microglial activation, and neuroinflammation at different CNS regions with olfactory neuritis (25%), nodular brainstem encephalitis (31%), and cranial nerve neuritis (6%) 199