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In cancer, the delicate balance of proteostasis is often disrupted, leading to the accumulation of misfolded or damaged proteins, aberrant signaling pathways, and genomic instability, all of which contribute to tumorigenesis and cancer progression

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Clinical Trial Findings Oral Bioavailability Challenge: Randomized controlled trials (RCTs) on standard oral GSH supplementation show mixed and controversial results

In this study, to examine the role of hepatic GSH depletion on protein oxidation and MASLD progression, we have overexpressed Chac1 specifically in liver to induce GSH depletion

Supplementary Figure S3 illustrates the spatial interplay of cofactor and substrate in the MSA-DH active site on the basis of the NAD(P) + and the MSA funnel