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The induction of neuroprotective genes, such as Bcl-2 and Bcl-xl, also contributes to HGF inhibition of apoptosis (Tsuzuki et al., 2000, 2001

MOTS-c may not fit research involving: Models where pure, rapid adipose tissue reduction is the only metric Research requiring oral bioavailability (MOTS-c is typically injected due to peptide degradation in the stomach) 5-Amino-1MQ may not fit research involving: Models focused on insulin sensitivity (it does not directly impact insulin receptors) Longevity research focused on mitochondrial biogenesis (it acts on NAD+ in fat, not mitochondrial genesis) Studies looking for exercise-mimetic effects on skeletal muscle Common Mistakes Mistake: Classifying 5-Amino-1MQ as a peptide

Several studies, including those from our laboratory, have reported cross-talk between S-palmitoylation and phosphorylation or ubiquitination 7,12,8188

Hariharan, N

ST/ESA/SER.A/348