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this generally results from genetic variability in the enzymes needed to produce and/or regenerate it 2

There are two primary types of melanin: Eumelanin: This is responsible for dark colors, such as black and brown

Proc Natl Acad Sci U S A 107:74197424

Those with autoimmune conditions are often low in glutathione levels

This response recruits neutrophils and mononuclear macrophages to the lungs, where they release superoxide anions, hydrogen peroxide and reactive oxygen species (ROS), thereby inducing oxidative stress in the airways (14)