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doi: 10.1158/1078-0432.CCR-14-1200 89 AnglinJZavarehRBSanderPNHaldarDMullarkyECantleyLCet al

Specifically, IGFBP3 was reported to inhibit tumorigenesis and cell growth, and IGFBP5 was suggested to function as a tumor suppressor [42,43,44,45]

Raffoul W, Far MS, Cayeux MC, Berger MM

Zn deficiency leads to greatly enhanced Mn uptake by cells, and this induces modifications to messenger RNA such that the ratio of guanine and cytosine nucleotides (C + G) to adenine and thymine (A + T) is sharply increased.[100] Clearly, more research is needed to explain the significance of these phenomena