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If poor dietary intake is responsible, oral supplements are often sufficient to restore normal levels

5 , eaav0316 (2019)

This is consistent with the Crabtree effect whereby glucose can inhibit cellular respiration and oxidative phosphorylation [60]

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Glutamine is imported into cells by distinct carriers from the families of Slc1, Slc6, Slc7, and Slc38 transporters, serving as an essential carbon and nitrogen source for many of these cells, including tumor cells (e.g., pancreatic ductal adenocarcinoma [170]), breast cancer cells [171], and immune cells