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doi: 10.3389/fmicb.2022.800219, 93 QuastC.PruesseE.YilmazP.GerkenJ.SchweerT.YarzaP.et al

In biochemical research systems, it modulates metabolic signaling by interfering with NNMT catalytic activity, thereby influencing levels of methylated nicotinamide derivatives and related metabolites

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Review of Studies Examining How Metformin Affects the Status of Specific Micronutrients and the Microbiome Vitamin B1 Vitamin B1 (thiamine) acts as a coenzyme in neurotransmission and low levels of this nutrient may have a role in the development of certain diabetic complications