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A general finding is that obese patients fulfilling criteria for MetS together with low IGF-1 plasma levels tend to develop a worse cardiovascular disease outcome than those with mid-normal to high-normal IGF-1 levels [213]

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These observations are exploratory and not conclusive

For comparisons between three or more groups, one-way analysis of variance (ANOVA) or Kruskall-Wallis tests were used, followed by the multiple comparison tests of Tukey or Dunn, for parametric or non-parametric data, respectively