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c , Liver samples were collected from mice treated with AAV8-GFP (n=8) or AAV8-AGXT (n=6), stained for Ly6G (green) and DAPI (blue) to visualize nuclei, analysed for ( d ) Ly6G+ cells and expressed as fold change from AAV8-GFP

In the HD model, reduced expression and deacetylase activity of SIRT3, which in turn prevents the deacetylation of LKB1 and SOD2, leading to a decrease in the level of NAD + , defects in mitochondrial biogenesis and accumulation of ROS

The expanding regulatory mechanisms and cellular functions of circular RNAs

FDH, formaldehyde dehydrogenase

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