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Early impairment of insulin sensitivity, -cell responsiveness, and insulin clearance in youth with stage 1 type 1 diabetes

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Importantly, in vivo and in vitro assays demonstrated that suppression of autophagy with chloroquine (CQ) and 3-methyladenine (3-MA) markedly heightened afatinib-induced cytotoxicity, indicating that autophagy serves as a protective response in lung adenocarcinoma cells treated with afatinib [15]