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Patients often exhibit low circulating VEGF in the face of significant tissue inflammation and endothelial injury

This modification results in dramatically different properties

For vitamin C, a daily dose of 500mg to 1,000mg is common for active adults

Makes it susceptible to rapid enzymatic degradation by peptidases in serum and tissues

In contrast, the Ph HAT dimeric interface is exclusively formed by -helical interactions, and, under this arrangement, the 1 strands are pushed away from the dimerisation interface (Supplementary Fig