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This idea is supported by other neurodegenerative diseases experiencing severe localized copper deficiency, such as the motor neurons of ALS patients (Hilton et al., 2024), PD patients with up to 50% reduction of copper seen in the substantia nigra (Bisaglia and Bubacco, 2020), brain copper reductions in prion diseases (Sorenson, 2001), and notably Menkes disease which is characterized by an X-linked defect in copper transporting ATP7-A gene that leads to severe systemic copper deficiency and progressive neurodegeneration (Tmer and Mller, 2010)

By age 40, most adults have lost up to 75% of the deep sleep they enjoyed in their twenties

doi: 10.1016/j.ymgme.2015.04.002

Expression Atlas: gene and protein expression across multiple studies and organisms

Finally, we examine the role of 5-HT 2A receptor-mediated neural inhibition in mediating the effects of these substances