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50 The microbiota plays a crucial role in various biological functions of the host, including the development of the immune system, protection from harmful microorganisms, food breakdown during digestion, and production of micronutrients and bioactive compounds

Impaired reproduction in heat-stressed cattle: basic and applied aspects

Many animal studies have reported that glutathione exerts an agonistic effect on NMDA receptors.8791 However, in the presence of uncontrolled and persistent chronic oxidative stress, glutathione level is decreased and leads to NMDA receptor dysfunction.9293 Deficits in glutathione level are associated with neurological deficits in various neuropsychiatric diseases.94 Glutathione regulates redox-sensitive sites such as the NMDA receptor

Acyl-CoA thioesters possess an electrophilic carbonyl-carbon and are able to undergo non-enzyme catalyzed transacylation reactions with biological nucleophiles leading to covalent binding to protein and drug-protein adduct formation