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Family Practice 2006;23:27985

NAD+ is naturally acidic and can cause significant injection site irritation

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Contrary to the aforementioned editorial claims, BTIs are often associated with worse outcomes, including severe or critical illness in ~11% of cases, linked to comorbidities like cardiovascular disease, and mortality rates around 0.9%substantially higher than the 0.03-0.05% infection fatality rate for natural SARS-CoV-2 infections in similar populations

Arteritic anterior ischemic optic neuropathy (AAION) and bilateral acute zonal occult outer retinopathy (AZOOR) are described as an abrupt presentation of photopsia and scotomas due to the damage of external retinal zones has been reported as adverse events