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Recurring events of T cell-mediated rejection can lead to chronic T cell-mediated rejection, where memory T cells at a low activation threshold can lead to graft rejection (48), along with other contributory factors such as repeat transplantation, tacrolimus (FK-506)-free immunosuppression regimen ( Regulatory T cells (Tregs) are lymphocytes that control the activity of other immune cells and are essential in the initiation and conservation of peripheral tolerance, hence maintaining a check on immune responses and autoimmunity

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Rose, C., Kresse, W