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[4] Note: as previously mentioned, the lipoyl-lysyl arm, arranged in an extended conformation and able to access the active site of pyruvate dehydrogenase where TPP is bound, enables the transfer of the acetyl group, generated by oxidation of hydroxyethylTPP, to the lipoamide moiety

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M Sharma J Burre 2023 Alpha-Synuclein in synaptic function and dysfunction Trends Neurosci 46 2 153 166 MG Spillantini M Goedert 2016 Synucleinopathies: past, present and future Neuropathol Appl Neurobiol DJ Surmeier JA Obeso GM Halliday 2017 Selective neuronal vulnerability in Parkinson disease Nat Rev Neurosci 18 2 101 113 Scheperjans F, Aho V, Pereira PA, Koskinen K, Paulin L, Pekkonen E, Haapaniemi E, Kaakkola S et al (2015) Gut microbiota are related to Parkinsons disease and clinical phenotype