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In one aspect of the invention, one or more NNMT inhibitors (such as a cation of Formula I or IA, or otherwise disclosed herein) is contacted with a cell expressing NNMT concurrently with one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that increase intracellular NAD+ levels to provide muscular therapy

In view of the emerging molecular subtypes of colon cancer and their suggested therapeutic implications, should we now assign treatment strategies based on these subtypes

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Tales from the crypt: new insights into intestinal stem cells