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The early identification of hepatotoxicity risk means promising drugs can undergo structural modifications to address toxicity issues and lower attrition rates

Evidence suggests that patients with CKD are prone to increased incidence of ischemic strokes, with cognitive dysfunction, dementia, transient infarcts, and white matter lesions widespread in mild to moderate CKD patients (Chelluboina and Vemuganti, 2019)

10.1016/B978-0-12-397169-2.00016-0 120 HamonM.BierneH.CossartP

Several of the described functions of redoxins are known for a long time but were not directly connected to ferroptosis

AB and CMP are funded by the UK Medical Research Council (grants MR/L014815/1, MR/J002739/1 and MR/N029488/1), the European Commission Horizon 2020 (grant SC1-BHC-01-2019) and the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and Kings College London