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Tesamorelin Originally developed for patients with HIV-related lipodystrophy, Tesamorelin has gained popularity for its ability to reduce visceral fat while preserving muscle mass

Data availability The Raw shotgun sequencing data that support the findings of this study have been deposited in the European Nucleotide Archive under accession codes PRJEB37249, PRJEB38742, PRJEB41311, and PRJEB46098

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Since ketone body metabolism is highly activated during calorie restriction or in glucose-deprived metabolic conditions, ketone bodies are considered crucial metabolites for calorie restriction-induced antiaging phenotypes 11