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Availability of data and materials Raw data of the transcriptome analyzed in this work are available at NCBI Sequence Read Archive ( with the accession number PRJNA822859

(2021) 16:e0250157

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Most patients with pernicious anaemia require lifelong treatment, and maintaining consistent therapy prevents recurrence of potentially serious complications

SLC39A11 may play a relatively minor role in the uptake of Mn in the liver, whereas SLC39A14 can mediate the uptake of Mn from the blood into hepatocytes in the liver and at the basolateral membrane of enterocytes in the intestine