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It also carries meaningful regulatory exposure exogenous HGH is a controlled substance with DEA-monitored prescribing, and off-label use carries significant risk

Nicotine can directly act on brain regions outside the mesolimbic dopamine system, such as the central linear nucleus and parabrachial nucleus, and manifests rewarding effects independent of dopamine through interactions with opioid receptors or other neuropeptides, suggesting a multi-system interactive rewarding integration mechanism (Neugebauer et al., 2011