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B12 is fundamental to a number of important metabolic processes, including: Red blood cell formation Nervous system function Nutrient absorption Adrenal gland support Cognitive function and memory Brain cell regeneration DNA synthesis Mitochondrial metabolism Male and female reproductive health Because of its important role in the nervous system, severe B12 depletion over time can lead to irreversible neurological damage

Excitation of methyl-, ethyl-, and n-propyl cobalamin at 520 nm in the low-lying absorption band results in bond homolysis proceeding via a bound cob(III)alamin MLCT state

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8,9 Manifestations Vitamin B 12 deficiency affects multiple systems, and sequelae vary in severity from mild fatigue to severe neurologic impairment 1,2,6,10 (Table 2 4,10 )

The dose is measured in milliliters (mL) or micrograms (mcg)