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10.1016/j.molmet.2021.101165 116 RobertiA.TejedorJ

[PubMed: 29653895] 186

This abnormal facilitation of motivational learning resulting from alcohol-induced stimulation of dopamine transmission is believed to underlie the neurobiology of alcohol addiction

While mechanical wear and tear are common culprits, nutritional gaps can fundamentally weaken joint structures, increase systemic joint pain , and accelerate the progression of osteoarthritis of the knee