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Thirty minutes after morphine administration (10 mg/kg, i.p.), mice were intragastrically administered a 0.25 mL suspension of 10% vegetable charcoal Norit A(Sigma-Aldrich) in 5% gum acacia (Sigma-Aldrich)

KPV's smaller molecule size and more targeted mechanism may contribute to its cleaner anecdotal side effect profile, though long-term human data do not exist for either compound