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This leads to a self-sustaining loop of neuroinflammation where cytokine release (especially IL-1 and TNF-) promotes more neuronal injury and mitochondrial dysfunction, resulting in persistent DAMP release Fig

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The conversion of the amino acid tryptophan to vitamin B3 also requires riboflavin and supports why B vitamin supplementation should be balanced

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Those antibodies could make future doses less effective, increase the risk of future reactions, or, in some therapeutic proteins, interfere with related natural proteins in the body