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However, despite the widespread nature of this condition, there are no internationally standardised guidelines regarding dosage regimes, optimal formulation, frequency of administration of B12 therapy and monitoring of therapeutic effect, leading to significantly variable international practice (Sobczyska-Malefora et al., 2021)

The complexity deepens when we consider that the majority of AD patients, especially in the elderly population, carry at least one of these vascular risk factorsapproximately 65% of individuals aged 65 and 80% of those aged 85 (Lokovic et al

J Neurosci 16: 25532562

Furthermore, in the studies by Borgstrm et al

J Nutr Biochem 1998