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The average weight loss achieved in the STEP 1 study of semaglutide for weight loss was 14.9% of the initial body weight over 68 weeks

In the intestines, butyrate plays a regulatory role on the transepithelial fluid transport, ameliorates mucosal inflammation and oxidative status, reinforces the epithelial defense barrier, and modulates visceral sensitivity and intestinal motility (Canani et al., 2011)