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124,125 Key diagnostic approaches include gastric emptying scintigraphy, the 13C-octanoic acid breath test, wireless motility capsule for gastroparesis, and esophageal manometry with pH monitoring for esophageal dysmotility

The nasal route facilitates non-invasive administration, avoiding the need for injections or complex delivery systems, which may simplify protocol designs during experimental procedures

L-NAME and L-arginine were commercially purchased (Sigma, United States)

Patients who expect dramatic changes after one session will be disappointed

Many patients follow an initial protocol over a few months, then reassess to decide whether to continue, adjust, or transition into a lighter maintenance plan