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Acknowledgements This work was supported by the National Natural Science Foundation of China (82272660, 82160456, and 81972399), the Guizhou Provincial Science and Technology Projects (ZK[2022]394), the Excellent Young Talents Plan of Guizhou Medical University ([2020]47), the Natural Science Foundation Research Team of Guangdong Province (2018B030312001), the Plan on Enhancing Scientific Research in GMU (02-410-2302289XM), the Basic and Applied Basic Research Project of the Guangzhou Basic Research Program (202201011411)

For context, the recommended dietary allowance for copper in adults is approximately 0.9 mg per day, and copper clearance from tissue through standard metabolic pathways appears efficient in animal models

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