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Zhenyukh O, Civantos E, Ruiz-Ortega M, Sanchez MS, Vazquez C, Peiro C, et al

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Carbamoyl phosphate synthetase is a key enzyme in the urea cycle, so impairment leads to urea cycle dysfunction with ammonia accumulation

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Some of the first symptoms of a metabolic crisis are: extreme sleepiness behavior changes irritable mood poor appetite Other symptoms then follow: fever nausea diarrhea vomiting hypoglycemia If a metabolic crisis is not treated, a child with CTD can develop: breathing problems swelling of the brain seizuresThese are also called "convulsions" or "fits." During a seizure, a person loses consciousness and control of his or her muscles