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Accumulation of cellular debris: Photoreceptor outer segments constantly shed and renewed with RPE phagocytosing old segments

Meanwhile, ferroptosisan iron-dependent programmed cell death (PCD) first reported by Dixon et al.has emerged as a key player in depression, with studies documenting its presence in neurons and glia and showing that suppressing it alleviates depressive-like behaviors (Dang et al., 2022

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