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For example, NOX4 promotes tumor growth and metastasis under hypoxic conditions, making selective NOX4 inhibitors potential treatments for hypoxia-inducible cancers

Betarbet et al., 2003)

These findings translate conceptually to human tendon injuries like those occurring in the shoulder

In this case its a powerful oxidative, and in enough concentrations, it can kill can cells, and in the presence of iron its toxicity can increase from 10 to 100 times (Eaton, 1991)