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The specific bioactivation mechanisms can vary depending on the drug and the enzyme(s) involved

Choudhury S

Genetics Some people are genetically predisposed to losing volume under the eyes

This deficiency promotes a vasospastic, prothrombotic, and inflammatory state in the vascular wall, which aligns with key Cerebral Small Vessel Disease mechanisms: hypoxia/ischemia and increased BBB permeability (Dobrynina et al., 2023)

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