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Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates methotrexate anticancer effects

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This advantage is significant since the increase in metabolic rate, which is associated with the abrupt restoration of normothermia, is postulated to be a secondary cause of IRI ( 2.3.3

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Supporting this hypothesis, animal tumor models have shown that selenium supplementation can decrease the occurence and severity of liver, esophageal, pancreatic, prostate, colon, and breast cancers (49)

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