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At 428.302(b)(4)(i), we proposed that if the manufacturer believes there are multiple events causing severe supply chain disruptions during the same applicable period for the same generic Part D rebatable drug or biosimilar and submits multiple rebate reduction requests for the same generic drug or biosimilar, CMS will grant no more than one rebate reduction for that generic drug or biosimilar for the applicable period

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Since the molecule has a high sequence identity to GPX4, except for the N-terminal region [19], it is likely that they are products of the same gene and are generated by an alternate promoter and exon usage of GPX4 [20]

This presents a significant challenge in the treatment of TNBC, where limited treatment options and poor outcomes necessitate the development of new therapeutic strategies to enhance treatment efficacy and suppress metastatic progression