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Registration and protocol: the present review was not registered

As the central nervous system becomes increasingly impaired, these critical functions dont receive the required signals from the brain, and they begin to shut down

Cells resuspended in the growth medium (GM, DMEM containing 10% fetal bovine serum (FBS, Life Technologies) and 1% anti-anti), and the single cells were seeded in a cell culture flask

Endogenous PRLMs are structurally unstable, rapidly metabolized, and possess short half-lives in vivo, limiting their direct application as therapeutic agents

These lower the chances of blood clot formation by enhancing blood flow and preventing vascular damage associated with vasoconstriction