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An intracellular scaffolding protein, Axin2 inhibits Wnt/-catenin signalling and negatively regulates -catenin and BMP2/4, thereby inhibiting osteoblast proliferation and differentiation [130, 131]

doi: 10.1016/j.cmet.2016.09.015

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The same LASSS treatment also conferred nitration resistance with a greater effect for Y198 than Y250, indicating a novel mechanism independent of an anti-oxidative function of LASSS