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This demonstrates the existence of IRS-1 dependent and -independent pathways of insulin/IGF-1 signaling

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[DOI] [PMC free article] [PubMed] [Google Scholar] 80.Martnez-Chantar M.L., Corrales F.J., Martnez-Cruz L.A., Garca-Trevijano E.R., Huang Z.-Z., Chen L., Kanel G., Avila M.A., Mato J.M., Lu S.C

Potential clinical interventions in osteoarthritis OA continues to be a significant global health concern since recent studies indicate alarming trends in its prevalence and associated disability