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Similar inhibitory effects on blood perfusion and permeability by monotherapy and combination therapy were also seen in the fibrosarcoma model (Fig

Lys240 is positioned close to Glu235 (~2.0 ), which together with Asn240 stabilizes a conserved water molecule

Consequently, further elucidation of Gln metabolic profiles and the utilisation of carriers, enzymes, or metabolites during aberrant energy metabolism as potential targets for cancer therapy would be expected to improve patient prognosis