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For instance, protein disulfide isomerase (PDI) deficiency, which induces misfolding stress in the ER, has been linked to disruptions in focal adhesions and cytoskeleton organization, particularly through the downregulation of MSN and CNN3 [70] both of which were observed to be downregulated in our proteomic analysis

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[DOI] [PMC free article] [PubMed] [Google Scholar] 53.Wu S., Yu W., Jiang X., Huang R., Zhang X., Lan J., Zhong G., Wan F., Tang Z., Hu L