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Preclinical studies in rodent models have evaluated outcomes such as fat oxidation, body-weight change patterns, and metabolic markers tied to fat breakdown and storage

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Because it chemically disables the NNMT enzyme in fat cells, it forces aggressive lipolysis and has been shown to prevent weight gain even in high-fat diet models

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Mechanism Selective NNMT inhibition, proposed to preserve intracellular NAD+/SAM and reduce fat-cell lipogenesis demonstrated in mice, not humans