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Preliminary study about the possible glycemic clinical advantage in using a fixed combination of Berberis aristata and Silybum marianum standardized extracts versus only Berberis aristata in patients with type 2 diabetes

869 FOXO3 attenuates OA progression by promoting the SLC7A11/GPX4 pathway and inhibiting the NF-B/MAPK pathway, thus inhibiting ferroptosis and extracellular matrix degradation in chondrocytes

The secondary outcomes will be the serum vitamin B12 concentration (pg/ml), adverse events (description, moment of onset and resolution, intensity, cause, steps taken), adherence to treatment (measured at each patient visit via the number of vials used for patients in the oral arm, and the number of injections given in the intramuscular arm), quality of life (measured using the EuroQoL-5D questionnaire), and patient satisfaction and preferences

World J Gastroenterol 25(32):4696 Barberino RS, Silva RLS, Palheta Junior RC, Smitz JEJ, Matos MHT (2023) Protective effects of antioxidants on cyclophosphamide-induced ovarian toxicity

If any discrepancies are noted, do not use the solution and consult with a healthcare provider