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However, annual review with your GP is advisable to: Ensure adherence to the injection schedule Monitor for any new or worsening symptoms Consider testing for other autoimmune conditions if symptoms develop (particularly thyroid function, as thyroid disease is commonly associated with pernicious anaemia) [2] Gastric cancer risk: Pernicious anaemia is associated with a slightly increased risk of gastric cancer

That means the realistic audience profile is descriptive rather than evidence-derived

doi: 10.1186/s13054-021-03545-1 123

Injection-site reactions (redness/itching/transient discomfort) Mild injection-site reactions were commonly reported Limited long-term safety data beyond ~12 weeks No serious adverse events directly attributed in published trials (per page) Use aseptic technique: wipe vial stopper with alcohol

For women, especially post-menopausal women, low B12 levels can have a serious impact on bone health