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Genetic mapping of GLCLC, the human gene encoding the catalytic subunit of gamma-glutamyl-cysteine synthetase, to chromosome band 6p12 and characterization of a polymorphic trinucleotide repeat within its 5 untranslated region

Preclinical studies have shown that mice deficient in C3aR/C5aR exhibit significantly reduced proteinuria, lower renal IgA and C3 deposition, diminished histological damage, and reduced mesangial proliferation in a Sendai virus-induced IgA nephropathy (IgAN) model (153)

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