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5 Potential therapeutic targets Up to now, clinical studies targeting SCFAs to improve NAFLD are scarce, and the direction of drug development is mostly based on the promotion of SCFA-producing advantageous microbiota, such as increasing the abundance of Bacteroidetes, Ackermannia, Bifidobacterium, Lactobacillus , and Prevotella , and decreasing the ratios of Firmicutes and F/B (Castillo et al., 2021)

doi: 10.1161/01.str.29.1.12

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As noted, NIK facilitates the interplay between B cells and T cells and promotes the differentiation of Tfh cells [67], a helper T cell subtype with increased frequency in lymph node biopsies of early stages of RA patients [130]

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