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Sphingolipids in obesity and correlated co-morbidities: the contribution of gender, Age and Environment

Comparing this to SmTGR structures lacking NADPH (PDB 2X8C), the phenol of Y296 is oriented approximately perpendicular to the isoalloxazine re-face, aligned with the central N1-N5 axis, and overlapping with the NADPH binding site (Figure 2)